One-hour diagnosis of heart attack possible with troponin T test from Roche

Novel strategy shortens time to heart attack diagnosis drastically, enabling faster start of treatment of patients and better use of healthcare resources.

Results from the TRAPID-AMI1 clinical study have been published online by the Annals of Emergency Medicine, confirming a novel approach for a more rapid diagnosis of heart attack in patients with acute chest pain. The strategy is based on the cardiac troponin T high-sensitivity test from Roche and reduces the observation time needed to rule-in or rule-out a heart attack from 3-6 hours to just 1 hour. It is well established that a fast and reliable diagnosis of heart attack is critical because every hour of delay from the onset of symptoms to treatment increases the mortality risk.

Every minute counts:

A heart attack, or acute myocardial infarction (AMI), is a common cardiac event in which the blood supply to an area of the heart muscle is interrupted, causing the muscle cells to die. Prompt treatment is essential as every 30 minutes of delay increases the relative risk of mortality by 7.5 % in patients with AMI. Patients with chest pain and other symptoms suggestive of AMI account for approximately 10-20% of all emergency room consultations and every 43 seconds, someone in the United States will have a heart attack.

Troponin is a heart muscle protein that is released into the blood stream during a heart attack. A limitation of the earlier generations of blood tests was the time required to detect the troponin release, sometimes requiring up to six hours with less sensitive troponin tests. The mortality rate of heart attacks is highest within hours of onset, so an early diagnosis and initiation of treatment greatly impacts outcome and potentially saves lives. The European Society of Cardiology adopted this accelerated diagnostic concept at their annual meeting held in London (UK) in August 2015. Their new clinical practice guidelines (2015 ESC NSTEMI) now support the 1-hour diagnostic algorithm with high-sensitive troponin testing validated in the TRAPID-AMI study.


  1. Acronym for: Cardiac troponin T–hs (high sensitivity) assay for RAPID rule-out of Acute Myocardial Infarction
  2. Multicenter Evaluation of a 0-Hour/1-Hour Algorithm in the Diagnosis of Myocardial Infarction With High-Sensitivity Cardiac Troponin T, Mueller, C. et al.,Annals of Emergency Medicine, doi: 10.1016/j.annemergmed.2015.11.013, published online 12 January 2016.


On March 30th, 2016, posted in: Blog by
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